Guanosine 5'-triphosphate-5'-adenosine (triammonium)

Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium, a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine triammonium is a fluorescent substrate analog[1][2].

Product Specifications

Product Name Alternative

GpppA (triammonium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/guanosine-5-triphosphate-5-adenosine-triammonium.html

Purity

99.97

Solubility

H2O : 116.67 mg/mL (ultrasonic) |H2O : 125 mg/mL

Smiles

O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C23)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(NC(N)=N6)=C(N=C5)C6=O)O4)(O)=O)(O)=O.N.N.N

Molecular Formula

C20H36N13O17P3

Molecular Weight

823.50

References & Citations

[1]Renata Kasprzyk, et al. Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity. Chemistry. 2020 Sep 1;26 (49) :11266-11275.|[2]Dennis Reichert, et al. Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chem Sci. 2021 Feb 8;12 (12) :4383-4388.