SPDB-DM4
SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.
Product Specifications
CAS Number
[1626359-62-3]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SPDB-DM4.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
Molecular Formula
C46H63ClN4O14S2
Molecular Weight
995.59
References & Citations
[1]Puja Sapra, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Investig Drugs. 2011 Aug;20 (8) :1131-49.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids
Available Sizes
Curated Selection
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