SMI-16a

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

Product Specifications

CAS Number

[587852-28-6]

Product Name Alternative

PIM1/2 Kinase Inhibitor VI

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SMI-16a.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC/1=O)SC1=C\C2=CC=C(OCCC)C=C2

Molecular Formula

C13H13NO3S

Molecular Weight

263.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52 (1) :74-86.|[2]Hiasa M, et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29 (1) :207-17.