SMI-16a
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.
Product Specifications
CAS Number
[587852-28-6]
Product Name Alternative
PIM1/2 Kinase Inhibitor VI
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SMI-16a.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC/1=O)SC1=C\C2=CC=C(OCCC)C=C2
Molecular Formula
C13H13NO3S
Molecular Weight
263.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52 (1) :74-86.|[2]Hiasa M, et al. Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma. Leukemia. 2015 Jan;29 (1) :207-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1; PIM2
Available Sizes
Curated Selection
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