SF3B1 (phospho-Thr313) rabbit pAb
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
Gene ID
23451
UniProt
O75533
Cellular Locus
Nucleus. Nucleus speckle. During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized phosho peptide around human SF3B1 (Thr313)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC
Validated Applications
WB,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IHC-p 1:50-300
Molecular Weight
145kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES13144-1.pdf
Observed Molecular Weight
145 kD
Subcellular Location
Nucleus . Nucleus speckle. During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
Other Product Names
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
Gene ID (Human)
23451
SwissProt (Human)
O75533
Available Sizes
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