9-Aminocamptothecin

9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity[1].

Product Specifications

CAS Number

[91421-43-1]

Product Name Alternative

9-Amino-20 (S) -camptothecin; 9-Amino-CPT

UNSPSC

12352005

Hazard Statement

H301

Target

Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9-aminocamptothecin.html

Purity

98.89

Solubility

DMSO : 3.33 mg/mL (ultrasonic)

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(N)C=CC=C5N=C4C3=C2)=O

Molecular Formula

C20H17N3O4

Molecular Weight

363.37

Precautions

H301

References & Citations

[1]Li ML, et al. Pharmacological determinants of 9-aminocamptothecin cytotoxicity. Clin Cancer Res. 2001 Jan;7 (1) :168-74.|[2]de Souza PL, et al. 9-Aminocamptothecin: a topoisomerase I inhibitor with preclinical activity in prostate cancer. Clin Cancer Res. 1997 Feb;3 (2) :287-94.|[3]Jeha S, et al. Activity of oral and intravenous 9-aminocamptothecin in SCID mice engrafted with human leukemia. Leuk Lymphoma. 1998 Dec;32 (1-2) :159-64.