AEBSF (hydrochloride)
AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
Product Specifications
CAS Number
30827-99-7
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Influenza Virus; Ser/Thr Protease; Thrombin
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/AEBSF.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl
Molecular Formula
C8H11ClFNO2S
Molecular Weight
239.69
Precautions
H315, H319
References & Citations
[1]Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17 (1) :171-9|[2]Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4- (2-aminoethyl) -benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60 (3) :328-36.|[3]Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 [3- (3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy) propane phosphonic acid] and AEBSF [4- (2-aminoethyl) -benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother.|[4]Jiang YH, et al. Serine protease inhibitor 4- (2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84 (6) :642-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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