AEBSF (hydrochloride)

AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

Product Specifications

CAS Number

[30827-99-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Influenza Virus; Ser/Thr Protease; Thrombin

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/AEBSF.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl

Molecular Formula

C8H11ClFNO2S

Molecular Weight

239.69

Precautions

H315, H319

References & Citations

[1]Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17 (1) :171-9|[2]Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4- (2-aminoethyl) -benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60 (3) :328-36.|[3]Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 [3- (3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy) propane phosphonic acid] and AEBSF [4- (2-aminoethyl) -benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother.|[4]Jiang YH, et al. Serine protease inhibitor 4- (2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84 (6) :642-8.