Loperamide
Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent[1].
Product Specifications
CAS Number
53179-11-6
Product Name Alternative
ADL 2-1294
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/loperamide.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N(C)C
Molecular Formula
C29H33ClN2O2
Molecular Weight
477.04
Precautions
H315, H319, H320
References & Citations
[1]DeHaven-Hudkins DL, et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289 (1) :494-502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Curr Med Sci. 2025 Aug 29.|Nature. 2025 Dec;648 (8094) :755-763.|Oncol Rep. 2025 Oct;54 (4) :133.|Phytomedicine. 2025 Oct 16:148:157417.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Dig Dis Sci. 2025 Nov 15.|eFood. 2025 Jul 14.|Food Qual Saf. 2024 Sep 10.|J Appl Microbiol. 2023 Aug 1;134 (8) :lxad153.|J Transl Med. 2021 Jul 23;19 (1) :317.|Viruses. 2021 Jun 28;13 (7) :1255.
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