Magic™ Membrane Protein Human CCR1 (C-C motif chemokine receptor 1)

The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). These chemokines and their receptor mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. CCR1-C-C Chemokine Receptor type 1-is one of the most prevalent targets for drug development according to the distribution of patents for small molecule inhibitors of chemokine receptors.