CDK8-IN-14
CDK8-IN-14 (compound 12) inhibits CDK8 with an IC50 value of 39.2 nM and has anti-AML cell proliferation activity (molm-13 GC50 = 0.02±0.01μM, MV4-11 GC50 = 0.03±0.01μM) [1].
Product Specifications
CAS Number
[2924193-12-2]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C1=CC=CC(C2=CN=C(NC=C3C4=COC=C4)C3=C2)=C1
Molecular Formula
C18H13N3O2
Molecular Weight
303.31
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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