Lithospermic acid

Lithospermic acid ((+) -Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4) -induced acute liver damage in vitro and in vivo[1].

Product Specifications

CAS Number

[28831-65-4]

Product Name Alternative

(+) -Lithospermic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Apoptosis; Keap1-Nrf2; NO Synthase; Xanthine Oxidase

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lithospermic-acid.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 66.67 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O

Molecular Formula

C27H22O12

Molecular Weight

538.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Chan KW, et al. Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo. Oncol Rep. 2015 Aug;34 (2) :673-80.|[2]Zhang M, et al., Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α (AMPKα) . Front Pharmacol. 2021 Nov 26;12:794982.|[3]Liu X, et al., Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats. Chem Biol Interact. 2008 Nov 25;176 (2-3) :137-42.