(R) - (+) -Bay-K-8644
(R) - (+) -Bay-K-8644 is a calcium channel inhibitor. (R) - (+) -Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM) .
Product Specifications
CAS Number
98791-67-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Bay-K-8644-_R_-__addition__-.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C([N+]([O-])=O)[C@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1
Molecular Formula
C16H15F3N2O4
Molecular Weight
356.30
Precautions
H315, H319
References & Citations
[1]Zhu HL, et al. Antagonistic actions of S (-) -Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba (2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378 (6) :609-15.|[2]Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9 (4) :e93803.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400218-500 1x 500 µL
CD100 (Semaphorin-4D) (A8), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
