(R) - (+) -Bay-K-8644

(R) - (+) -Bay-K-8644 is a calcium channel inhibitor. (R) - (+) -Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM) .

Product Specifications

CAS Number

[98791-67-4]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Bay-K-8644-_R_-__addition__-.html

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C([N+]([O-])=O)[C@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1

Molecular Formula

C16H15F3N2O4

Molecular Weight

356.30

Precautions

H315, H319

References & Citations

[1]Zhu HL, et al. Antagonistic actions of S (-) -Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba (2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378 (6) :609-15.|[2]Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9 (4) :e93803.