VU0364739
VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM) . VU0364739 decreases cancer cell proliferation[1].
Product Specifications
CAS Number
1244639-78-8
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vu0364739.html
Purity
99.16
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C=CC=C2)C=C1)NCCN3CCC4(CC3)C(NCN4C5=CC(F)=CC=C5)=O
Molecular Formula
C26H27FN4O2
Molecular Weight
446.52
References & Citations
[1]Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N- (2- (4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl) ethyl) benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53 (18) :6706-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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