Apecotrep
Apecotrep (TRPC6-IN-3) (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. Apecotrep modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. Apecotrep can be used in research of respiratory system[1].
Product Specifications
CAS Number
[2311863-36-0]
Product Name Alternative
TRPC6-IN-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trpc6-in-3.html
Purity
99.17
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C2=NN=C(N)C=C2)CC1)C3=NC=C(OC4=CC=C(F)C=C4)C(OC)=C3
Molecular Formula
C22H22FN5O3
Molecular Weight
423.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Thierry B, et, al. Inhibitors of TRPC6 for treating respiratory conditions. WO2021209510.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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