VCC972839:01
VCC972839:01 is an inhibitor for cyclin dependent kinase (CDK9), with IC50 of 7 nM. VCC972839:01 inhibits the cell viability of SCLC cells in nanomolar levels. VCC972839:01 induces apoptosis through an intrinsic pathway. VCC972839:01 exhibits antitumor activity in mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vcc972839-01.html
Smiles
COC1=CC=CC=C1C2=NC=NC(NC3=CC(CN4C=NC5=C4C=CC=C5)=CC=C3)=N2
Molecular Formula
C24H20N6O
Molecular Weight
408.46
References & Citations
[1]Valdez Capuccino L, et al., CDK9 inhibition as an effective therapy for small cell lung cancer. Cell Death Dis. 2024 May 20;15 (5) :345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
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