Human Beta-NGF Protein, premium grade

Nerve growth factor beta (beta-NGF) is a neurotrophic factor that plays critical role in the development and maintenance of sensory and sympathetic neurons. The active form of human beta-NGF is is a noncovalently disulfide-linked homodimer, which is secreted and signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways.

Product Specifications

Background

Specifications

This protein carries no "tag". The protein has a calculated MW of 13.5 kDa. The protein migrates as 14-15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P01138

Expression Region

Ser 122 - Ala 241

Host

HEK293

Target

Beta-NGF

Conjugation

Unconjugated

Tag

Native

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

0.01 EU per μg

Purity

90%

Bioactivity

Immobilized Human Beta-NGF Protein, premium grade (Cat. No. BEF-H5214) at 1 μg/mL (100 μL/well) can bind Human TrkA (33-417), Mouse IgG2a Fc Tag (Cat. No. TRA-H5259) with a linear range of 1-16 ng/mL (QC tested).

Format

Powder

Buffer

20 mM NaAC, 150 mM NaCl, pH5.5

Additives

Trehalose

Molecular Weight

13.5 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Storage Conditions

-20°C

Package Size

20ug*1

Host or Source

HEK293

Species

Human

Protein ID

P01138

Preservative

Trehalose

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