Belinostat
Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
Product Specifications
CAS Number
866323-14-0
Product Name Alternative
PXD101; PX105684
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HDAC
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Belinostat.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(NC1=CC=CC=C1)(C2=CC(/C=C/C(NO)=O)=CC=C2)=O
Molecular Formula
C15H14N2O4S
Molecular Weight
318.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Plumb JA, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histonedeacetylase inhibitor PXD101. Mol Cancer Ther. 2003 Aug;2 (8) :721-8.|[2]Qian X, et al. Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther. 2006 Aug;5 (8) :2086-95.|[3]Chia S, et al. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nat Commun. 2017 Sep 5;8 (1) :435.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HDAC; HDAC6
Available Sizes
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