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1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction[1][2].

Product Specifications

CAS Number

[89576-29-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H331, H336, H351, H372

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/1-oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine.html

Purity

99.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(OCCN)(O)=O)=O

Molecular Formula

C23H46NO7P

Molecular Weight

479.59

Precautions

H302, H315, H319, H331, H336, H351, H372

References & Citations

[1]Yamamoto Y, et al. Analysis of serum lysophosphatidylethanolamine levels in patients with non-alcoholic fatty liver disease by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2021 Jan;413 (1) :245-254.|[2]Inoue N, et al. Determination of plasma lysophosphatidylethanolamines (lyso-PE) by LC-MS/MS revealed a possible relation between obesity and lyso-PE in Japanese preadolescent children: The Hokkaido study. Ann Clin Biochem. 2025 Jan;62 (1) :34-45.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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