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Senazodan (hydrochloride)

Product Specifications

UNSPSC Description

Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III[1][2].

Target Antigen

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/senazodan-hydrochloride.html

Purity

99.84

Solubility

DMSO : 67.5 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C1CCC(C2=CC=C(NC3=CC=NC=C3)C=C2)=NN1

Molecular Weight

302.76

References & Citations

[1]Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203.|[2]Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70.|[3]Yang G, et al. Effects of MCI-154 on vascular reactivity and its mechanisms after hemorrhagic shock in rats. J Cardiovasc Pharmacol. 2006;47(6):751-757.|[4]Ming MJ, et al. Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits. Shock. 2000;13(6):459-463.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101693A/Senazodan-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101693A/Senazodan-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

98326-33-1

Available Sizes

Curated Selection

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