A-966492
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
Product Specifications
CAS Number
[934162-61-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-966492.html
Concentration
10mM
Purity
99.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC([C@H]2NCCC2)=CC=C1C3=NC4=C(C(N)=O)C=CC=C4N3
Molecular Formula
C18H17FN4O
Molecular Weight
324.35
Precautions
H302, H315, H319
References & Citations
[1]Penning TD, et al. Optimization of phenyl-substituted benzimidazole carboxamide poly (ADP-ribose) polymerase inhibitors: identification of (S) -2- (2-fluoro-4- (pyrrolidin-2-yl) phenyl) -1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2
Available Sizes
Curated Selection
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