A-966492
Product Specifications
UNSPSC Description
A-966492 is a novel and potent inhibitor of?PARP1?and?PARP2?with?Ki of 1 nM and 1.5 nM, respectively.
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-966492.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC([C@H]2NCCC2)=CC=C1C3=NC4=C(C(N)=O)C=CC=C4N3
Molecular Weight
324.35
References & Citations
[1]Penning TD, et al. Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10614/A-966492-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10614/A-966492-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
934162-61-5
Available Sizes
Curated Selection
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