A-966492

A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

Product Specifications

CAS Number

[934162-61-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-966492.html

Concentration

10mM

Purity

99.00

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC([C@H]2NCCC2)=CC=C1C3=NC4=C(C(N)=O)C=CC=C4N3

Molecular Formula

C18H17FN4O

Molecular Weight

324.35

Precautions

H302, H315, H319

References & Citations

[1]Penning TD, et al. Optimization of phenyl-substituted benzimidazole carboxamide poly (ADP-ribose) polymerase inhibitors: identification of (S) -2- (2-fluoro-4- (pyrrolidin-2-yl) phenyl) -1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious