8-Chloroadenosine
8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].
Product Specifications
CAS Number
[34408-14-5]
Product Name Alternative
8-Cl-Ado
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
AMPK; Autophagy; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-chloroadenosine.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
Molecular Formula
C10H12ClN5O4
Molecular Weight
301.69
Precautions
H302, H315, H319, H332, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103400/8-Chloroadenosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103400/8-Chloroadenosine-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AMPK
Available Sizes
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