8-Chloroadenosine

8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].

Product Specifications

CAS Number

[34408-14-5]

Product Name Alternative

8-Cl-Ado

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

AMPK; Autophagy; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-chloroadenosine.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO

Molecular Formula

C10H12ClN5O4

Molecular Weight

301.69

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.