Phoenixin-20 (TFA)

Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect[1][2][3].

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[1]Yang Y, et al. Phoenixin 20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. J Mol Histol. 2020;51(2):173-181.|[2]Jiang JH, et al. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48.|[3]Rajeswari JJ, et al. Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish. Sci Rep. 2020;10(1):6264.