CFTR corrector 8
CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].
Product Specifications
CAS Number
1918142-35-4
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cftr-corrector-8.html
Purity
96.00
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC
Molecular Formula
C29H27F2NO7
Molecular Weight
539.52
References & Citations
[1]Wang X, et al. Discovery of 4-[ (2R,4R) -4- ({[1- (2,2-Difluoro-1,3-benzodioxol-5-yl) cyclopropyl]carbonyl}amino) -7- (difluoromethoxy) -3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61 (4) :1436-1449.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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