CFTR corrector 8

CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].

Product Specifications

CAS Number

[1918142-35-4]

UNSPSC

12352005

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cftr-corrector-8.html

Purity

96.00

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC

Molecular Formula

C29H27F2NO7

Molecular Weight

539.52

References & Citations

[1]Wang X, et al. Discovery of 4-[ (2R,4R) -4- ({[1- (2,2-Difluoro-1,3-benzodioxol-5-yl) cyclopropyl]carbonyl}amino) -7- (difluoromethoxy) -3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61 (4) :1436-1449.