What is the catalog number for H-1152?

The catalog number for H-1152 is HY-15720.

What sizes are available for H-1152?

H-1152 is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does H-1152 come in?

H-1152 is available in 2 different pack sizes.

H-1152 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures H-1152?

H-1152 is manufactured by QuantiMol.

What is the estimated delivery time for H-1152?

Estimated delivery time for H-1152 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for H-1152?

The safety data sheet for H-1152 is available here: http://file.medchemexpress.com/batch_PDF/HY-15720/H-1152-SDS-MedChemExpress.pdf.

H-1152

H-1152 is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.

Product Specifications

CAS Number

451462-58-1

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/h-1152.html

Purity

98.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CN=CC2=C1C(S(=O)(N3[C@@H](C)CNCCC3)=O)=CC=C2

Molecular Formula

C16H21N3O2S

Molecular Weight

319.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754 (1-2) :245-52. Epub 2005 Sep 12.|[2]Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81 (1) :9-16.|[3]Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169 (2) :855-62.