ASCT2-IN-2
ASCT2-IN-2 (compound 25e) is an ASCT2 inhibitor with IC50 of 5.14 μM. ASCT2-IN-2 regulates amino acid metabolism as well as mTOR signaling and thereby induces cell apoptosis. ASCT2-IN-2 inhibits tumor growth[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ASCT; Autophagy; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/asct2-in-2.html
Purity
99.10
Solubility
DMSO : ≥ 150 mg/mL
Smiles
N[C@@H](CCN(CC1=C(C=CC(C(C)(C)C)=C1)OCC#CC2=CC=CC=C2)CC3=CC(C(C)(C)C)=CC=C3OCC#CC4=CC=CC=C4)C(O)=O
Molecular Formula
C44H50N2O4
Molecular Weight
670.88
References & Citations
[1]Qin L et al., Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c01093
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC434156 20 µg
Cyclophilin E (PPIE) (NM_001195007) Human Over-expression Lysate
Sign In for Pricing
View Details 
E-UNEL-M0164-01 5x 96 Tests
Uncoated Mouse ALPL (Alkaline Phosphatase, Liver/Bone/Kidney) ELISA Kit
Sign In for Pricing
View Details E-UNEL-M0164-02 15x 96 Tests
Uncoated Mouse ALPL (Alkaline Phosphatase, Liver/Bone/Kidney) ELISA Kit
Sign In for Pricing
View Details 