3'-Deoxyuridine-5'-triphosphate (trisodium)

3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].

Product Specifications

Product Name Alternative

3'-dUTP (trisodium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-deoxyuridine-5-triphosphate-trisodium.html

Purity

99.69

Solubility

H2O : 20 mg/mL (ultrasonic)

Smiles

O=P(O)(O[Na])OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C9H12N2Na3O14P3

Molecular Weight

534.09

References & Citations

[1]M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9 (13) :3129-38.