Dimebutic acid
Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid can be used in the study of β-thalassemia and sickle cell disease[1][2].
Product Specifications
CAS Number
595-37-9
Product Name Alternative
NSC-16045; NSC-741804
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dimebutic-acid.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCC(C)(C)C(O)=O
Molecular Formula
C6H12O2
Molecular Weight
116.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Parise RA, et al. Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862 (1-2) :168-74.|[2]Terse PS, et al. Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats. Toxicol Pathol. 2011 Jun;39 (4) :614-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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