Dimebutic acid

Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid can be used in the study of β-thalassemia and sickle cell disease[1][2].

Product Specifications

CAS Number

[595-37-9]

Product Name Alternative

NSC-16045; NSC-741804

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dimebutic-acid.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CCC(C)(C)C(O)=O

Molecular Formula

C6H12O2

Molecular Weight

116.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Parise RA, et al. Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862 (1-2) :168-74.|[2]Terse PS, et al. Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats. Toxicol Pathol. 2011 Jun;39 (4) :614-22.