Regorafénib N-oxyde-d3 (M2)
Regorafénib N-oxyde-d3 (M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].
Product Specifications
CAS Number
1333489-03-4
UNSPSC
12352005
Target
Drug Metabolite; PDGFR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])NC(C1=CC(OC2=CC(F)=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=[N+]1[O-])=O
Molecular Formula
C21H12D3ClF4N4O4
Molecular Weight
501.83
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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