Martinostat (hydrochloride)
Martinostat hydrochloride is a HDAC inhibitor and can be labeled with radionuclides for quantitative imaging of HDACs in vivo in the central nervous system and major peripheral organs[1][2].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/martinostat-hydrochloride.html
Purity
99.01
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CN(CC(C=C1)=CC=C1/C=C/C(NO)=O)CC2(C[C@@H](C3)C4)C[C@@H]4C[C@@H]3C2.[H]Cl
Molecular Formula
C22H31ClN2O2
Molecular Weight
390.95
References & Citations
[1]Changning Wang, et al. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs. J Med Chem. 2014 Oct 9;57 (19) :7999-8009. |[2]Tharick A Pascoal, et al. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease. Nat Commun. 2022 Jul 19;13 (1) :4171.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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