Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Aclacinomycin A

Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis[1][2][3].

Product Specifications

CAS Number

57576-44-0

Product Name Alternative

Aclarubicin

UNSPSC

12171500

Hazard Statement

H301

Target

Antibiotic; DNA/RNA Synthesis; Proteasome; Topoisomerase

Type

Dye Reagents

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aclacinomycin-a.html

Purity

99.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1C2=CC(C(C3=CC=CC(O)=C43)=O)=C(C4=O)C(O)=C2[C@@H](O[C@@](O[C@@H](C)[C@H]5O[C@@](O[C@@H](C)[C@H]6O[C@](CCC7=O)([H])O[C@H]7C)([H])C[C@@H]6O)([H])C[C@@H]5N(C)C)C[C@]1(O)CC)OC

Molecular Formula

C42H53NO15

Molecular Weight

811.87

Precautions

H301

References & Citations

[1]Isoe T, et al. Inhibition of different steps of the ubiquitin system by CDDP and aclarubicin. Biochim Biophys Acta. 1992 Sep 15;1117 (2) :131-5.|[2]Hajji N, et al. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2;583 (1) :26-35.|[3]Iihoshi H, et al. Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol Lett. 2017 Aug 5;277:109-114. |[4]Hori S, Shirai M, Hirano S, Oki T, Inui T, Tsukagoshi S, Ishizuka M, Takeuchi T, Umezawa H. Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. Gan. 1977 Oct;68 (5) :685-90.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Dye Reagents

Clinical Information

Launched

Isoform

Topo I; Topo II

Citation 01

Biomolecules. 2025 Jul 6.|Patent. US20250129329A1.|Bioengineered. 2022 Feb;13 (2) :2207-2216.|bioRxiv. 2023 Jan 13.|Int J Hyperthermia. 2022;39 (1) :998-1009.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

SMAD1 Human Gene Knockout Kit (CRISPR)
KN400299 1 Kit

SMAD1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
PIWIL3 (NM_001008496) Human Over-expression Lysate
LY423442 100 µg

PIWIL3 (NM_001008496) Human Over-expression Lysate

Sign In for Pricing
View Details
SPATA2L Rabbit Polyclonal Antibody
TA372986 100 µL

SPATA2L Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Anti-ZFP161
Y058662 100 µL

Anti-ZFP161

Sign In for Pricing
View Details
CCDC110 Rabbit Polyclonal Antibody
TA374336 100 µL

CCDC110 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
SPINK5 Human Knockdown Lysate
LY300299 100 µg

SPINK5 Human Knockdown Lysate

Sign In for Pricing
View Details