Trans-Cyclohexane-1,2-diol

Trans-Cyclohexane-1,2-diol (TCHD) is a transient dilator of the nuclear pore complex (NPC) . By interacting with the hydrophobic core (FG nucleoporin) of the NPC, trans-Cyclohexane-1,2-diol can disrupt the NPC structure and reversibly increase the permeability of the nuclear pore, allowing macromolecules larger than 40 kDa (such as plasmid DNA) to enter the cell nucleus by passive diffusion, thereby enhancing the nuclear import efficiency of non-viral vectors. trans-Cyclohexane-1,2-diol can improve the efficiency of in vitro electrotransfection or lipid-mediated gene transfection, especially significantly increasing gene expression in differentiated airway epithelial cells[1][2].

Product Specifications

CAS Number

[1460-57-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/trans-cyclohexane-1-2-diol.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](O)CCCC1

Molecular Formula

C6H12O2

Molecular Weight

116.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Griesenbach U, et al. Assessment of the nuclear pore dilating agent trans-cyclohexane-1,2-diol in differentiated airway epithelium. J Gene Med. 2012 Jul;14 (7) :491-500.|[2]Pasquet L, et al. Post-pulse addition of trans-cyclohexane-1,2-diol improves electrotransfer mediated gene expression in mammalian cells. Biochem Biophys Rep. 2016 Jul 17;7:287-294.