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Box5 (TFA)

Box5 TFA is a potent Wnt5a antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma[1].

Product Specifications

UNSPSC

12352209

Target

Wnt

Type

Peptides

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/box5-tfa.html

Purity

99.24

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC(OC(C)(C)C)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C32H51F3N6O15S2.xC2HF3O2

Molecular Weight

880.90 (free base)

References & Citations

[1]Jenei V, et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A. 2009 Nov 17;106 (46) :19473-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

Wnt5

Citation 01

Adv Sci (Weinh) . 2025 Jun 24:e02774.|J Immunother Cancer. 2025 Mar 22;13 (3) :e010555.|Oral Dis. 2024 May 8.|J Mol Cell Biol. 2025 Jul 28;17 (2) :mjaf002.|J Neuroinflammation. 2024 Mar 26;21 (1) :75.|J Transl Med. 2025 Mar 6;23 (1) :282.|Nano Today. 2024 Apr, 55, 102201.

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