RNF8, Human (sf9, His, Myc)

RNF8 protein is an important E3 ubiquitin protein ligase that participates in the recruitment of repair proteins through "Lys-63" linked histone ubiquitination and "Lys-48" linked ubiquitination to clear damage sites. target protein, thereby participating in DNA damage signaling. RNF8 is recruited by ATM-phosphorylated MDC1 to form ionizing radiation-induced foci of TP53BP1 and BRCA1 at double-strand breaks. RNF8 Protein, Human (sf9, His, Myc) is the recombinant human-derived RNF8, expressed by Sf9 insect cells, with C-Myc, N-10*His labeled tag.