(6S,12aR) -Tadalafil

(6S,12aR) -Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity[1].

Product Specifications

CAS Number

[171596-28-4]

Product Name Alternative

Tadalafil EP Impurity C; (6S,12aR) -IC-351

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cis-ent-tadalafil.html

Purity

99.34

Solubility

10 mM in DMSO

Smiles

O=C([C@@]1([H])CC2=C([C@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O

Molecular Formula

C22H19N3O4

Molecular Weight

389.40

Precautions

H315, H319, H335

References & Citations

[1]Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46 (21) :4533-42.