NRX-103094

NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM[1].

Product Specifications

CAS Number

[2763260-36-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Molecular Glues; β-catenin

Type

Reference compound

Related Pathways

PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nrx-103094.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O

Molecular Formula

C20H11Cl2F3N2O4S

Molecular Weight

503.28

Precautions

H302, H312, H332

References & Citations

[1]Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10 (1) :1402.