SARS-CoV-2 3CLpro-IN-29

3CLPro-IN-3 (Compound A36) is an inhibitor for SARS-CoV-2 3CLpro with IC50 of 51.3 nM. 3CLPro-IN-3 exhibits antiviral activity against human coronavirus 229E, OC43 and mouse hepatitis virus MHV[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-3clpro-in-29.html

Smiles

CN1C=NC(CN2C(C=C(N(C2=O)CC3=C(C=C(C(F)=C3)F)F)NC4=CC5=CN(C(C)C)N=C5C=C4Cl)=O)=N1

Molecular Formula

C25H22ClF3N8O2

Molecular Weight

558.94

References & Citations

[1]Pan F, et al., Development of pyrimidone derivatives as nonpeptidic and noncovalent 3-chymotrypsin-like protease (3CLpro) inhibitors with anti-coronavirus activities. Bioorg Chem. 2024 Nov 22;154:107988.