Osteogenic Growth Peptide (10-14)

Osteogenic Growth Peptide (10-14) (OGP (10-14) ), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].

Product Specifications

CAS Number

[105250-85-9]

Product Name Alternative

OGP (10-14) ; Historphin

UNSPSC

12352209

Target

Src

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/osteogenic-growth-peptide-10-14.html

Purity

99.51

Solubility

DMSO : 8.93 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C=C1)=CC=C1C[C@H](N)C(NCC(N[C@H](C(NCC(NCC(O)=O)=O)=O)CC2=CC=CC=C2)=O)=O

Molecular Formula

C24H29N5O7

Molecular Weight

499.52

References & Citations

[1]Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP (10-14) . J Med Chem. 2002;45 (8) :1624-1632.|[2]Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP (10-14) ]. Protein Pept Lett. 2009;16 (9) :1074-1080.|[3]Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP) -derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26 (1) :19-27.|[4]Battolla B, et al. The small peptide OGP (10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17 (1) :SC1-SC5.