Kurarinol
Product Specifications
UNSPSC Description
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].
Target Antigen
Apoptosis; Tyrosinase
Type
Natural Products
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kurarinol.html
Solubility
10 mM in DMSO
Smiles
CC([C@H](CCC(C)(O)C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)CC3=O)C3=C1OC)=C
Molecular Weight
456.53
References & Citations
[1]Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.|[2]Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.|[3]Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122933/Kurarinol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122933/
Clinical Information
No Development Reported
CAS Number
855746-98-4
Available Sizes
Curated Selection
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