Kurarinol

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].

Product Specifications

CAS Number

[855746-98-4]

UNSPSC

12352005

Target

Apoptosis; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kurarinol.html

Solubility

10 mM in DMSO

Smiles

CC([C@H](CCC(C)(O)C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)CC3=O)C3=C1OC)=C

Molecular Formula

C26H32O7

Molecular Weight

456.53

References & Citations

[1]Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15 (8) :612-8.|[2]Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281 (2) :157-65.|[3]Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31 (1) :73-8.