1-Acetyl-β-carboline

1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin[1][2][3].

Product Specifications

CAS Number

[50892-83-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite; PERK; Tyrosinase

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/1-acetyl-β-carboline.html

Purity

97.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1=NC=CC2=C1NC3=CC=CC=C32)=O

Molecular Formula

C13H10N2O

Molecular Weight

210.23

Precautions

H302, H315, H319, H335

References & Citations

[1]PROKSA B, et al. 1-Acetyl-β-carboline, a new metabolite of Streptomyces kasugaensis. Acta Biotechnologica (Acta Biotechnol) . Volume: 10 Issue: 4 Page: 337-340 Publication year: 1990.|[2]Shin H J, et al. The Synergistic Antibacterial Activity of 1-Acetyl--Carboline and -Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA) . Journal of microbiology and biotechnology, 2010, 20 (3) : 501-505.|[3]Hyun KA, et al. 1-Acetyl-β-Carboline from a Jeju Gotjawal Strain Lentzea sp. JNUCC 0626 and Its Melanogenic Stimulating Activity in B16F10 Melanoma Cells. Molecules. 2024 Sep 27;29 (19) :4586.