Trimethadione

Trimethadione (3,5,5, -Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects[1][2].

Product Specifications

CAS Number

[127-48-0]

Product Name Alternative

3,5,5, -Trimethyloxazolidine-2,4-dione

UNSPSC

12352005

Hazard Statement

H312, H332, H360

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Trimethadione.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C)OC(C)(C)C1=O

Molecular Formula

C6H9NO3

Molecular Weight

143.14

Precautions

H312, H332, H360

References & Citations

[1]Pastore V, et, al. Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides. Bioorg Med Chem. 2013 Feb 15;21 (4) :841-6.|[2]Barton ME, et, al. The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol. 2005 Oct 3;521 (1-3) :79-85.|[3]Shen H, et al., Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res. 2007 Apr;226 (1-2) :52-60.