MMV009085
MMV009085 is a potent PfHT1 (Plasmodium falciparum hexose transporter) -specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC50: 2.6 μM in glucose uptake assay) and growth of the parasites (EC50: 1.23±0.04 μM against 3D7) [1].
Product Specifications
CAS Number
[298217-59-1]
UNSPSC
12352005
Target
GLUT; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mmv009085.html
Purity
95.0
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=C3C(N(CCCCO)C(C4=CC=C(C2=C34)C(N1CCCCO)=O)=O)=O
Molecular Formula
C22H22N2O6
Molecular Weight
410.42
References & Citations
[1]Xin Jiang, et al. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.Cell. 2020 Oct 1;183 (1) :258-268.e12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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