LCL521 dihydrochloride

LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) [1].

Product Specifications

CAS Number

[1226759-47-2]

UNSPSC

12352005

Hazard Statement

H225, H350

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LCL521_dihydrochloride.html

Purity

98.12

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(CN(C)C)O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@@H](COC(CN(C)C)=O)NC(CCCCCCCCCCCCC)=O.[H]Cl.[H]Cl

Molecular Formula

C31H54Cl2N4O7

Molecular Weight

665.69

Precautions

H225, H350

References & Citations

[1]Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22 (24) :6933-44.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Hum Mol Genet. 2025 Nov 13.|Nat Immunol. 2023 May;24 (5) :802-813.

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