LCL521 dihydrochloride
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) [1].
Product Specifications
CAS Number
1226759-47-2
UNSPSC
12352005
Hazard Statement
H225, H350
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LCL521_dihydrochloride.html
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(CN(C)C)O[C@H](C1=CC=C([N+]([O-])=O)C=C1)[C@@H](COC(CN(C)C)=O)NC(CCCCCCCCCCCCC)=O.[H]Cl.[H]Cl
Molecular Formula
C31H54Cl2N4O7
Molecular Weight
665.69
Precautions
H225, H350
References & Citations
[1]Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22 (24) :6933-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Hum Mol Genet. 2025 Nov 13.|Nat Immunol. 2023 May;24 (5) :802-813.
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