FGD1 rabbit pAb
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16. [provided by RefSeq, Mar 2011],
Product Specifications
Background
Product Name Alternative
UniProt
P98174
Swiss Prot
P98174
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human FGD1 AA range: 508-558
Target
FGD1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
105kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
105kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Associated with membrane ruffles and lamellipodia. .
Other Product Names
Gene ID (Human)
2245
Available Sizes
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