VU590
Product Specifications
UNSPSC Description
VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney[1][2].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vu590.html
Purity
96.35
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
[O-][N+](C1=CC=C(C=C1)CN(CCOCCOCC2)CCOCCN2CC(C=C3)=CC=C3[N+]([O-])=O)=O
Molecular Weight
488.53
References & Citations
[1]Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.|[2]Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108595/VU590-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108595/VU590-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
313505-85-0
Available Sizes
Curated Selection
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