Fomivirsen (sodium)
Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].
Product Specifications
CAS Number
[160369-77-7]
Product Name Alternative
ISIS-2922 sodium
UNSPSC
12352208
Target
CMV
Type
Oligonucleotides
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fomivirsen-sodium.html
Purity
99.54
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Fomivirsen(sodium)]
Molecular Formula
C204H263N63O114P20S20.20Na
Molecular Weight
6682.4 (free acid)
References & Citations
[1]M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7 (3-4) :189-98.|[2]Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Available Sizes
Curated Selection
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